Siobhan Greene started her career at Yorkshire Television in Leeds as a typist. She worked as a runner, then researcher on The Time The Place, and fly on the wall documentary series Jimmy’s, before moving to Granada in Manchester to work on Stars in their Eyes and You've Been Framed. During her time she co-created Popstars the Rivals and Ant and Dec's Saturday Night Takeaway.
In 2003 she left ITV to set up Syco Television alongside Simon Cowell and Nigel Hall where they co-created and executive produced The X Factor from 2004, and Britain's Got Talent from 2007. They have since become two of the biggest talent show franchises of all time. She returned to ITV to become Director of Entertainment for ITV Studios in 2012 where she executive produced the return of Ant and Dec's Saturday Night Takeaway, and launched Love Island on ITV2, and in 2015 launched the US version of Saturday Night Takeaway in the USA on NBC, renamed, Best Time Ever with Neil Patrick Harris.
Last year Greene became Head of Entertainment Commissioning for ITV, responsible for The X Factor, Britain's Got Talent, I'm A Celebrity Get Me Out of Here, Ant and Dec's Saturday Night Takeaway, The Voice and The Voice Kids. She also has a brief to commission new shows and her first have been announced - namely Last Laugh in Vegas and Ant and Dec's DNA Journey.